Simvastatin_Structural_Formulae Tags: Simvastatin View |
Simvastatin (INN (International Nonproprietary Name)) (pronEng?s?mv?st�t?n), (marketed under the trade names Zocor, Simlup, Simcard, Simvacor, and others, as well as generically) is a hypolipidemic drug (hypolipidemic agent) belonging to the class of pharmaceuticals called "statins". It is used to control hypercholesterolemia (elevated cholesterol levels) and to prevent cardiovascular disease. Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus.
Iupac Name: (1''S'',3''R'',7''S'',8''S'',8''aR'')-8-2-(2''R'',4''R'')-4-hydroxy-6-oxooxan-2-ylethyl-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Casno Ref: cascite
Number on List: 79902-63-9
Chemspiderid: 49179
Atc Prefix: C10
Atc Suffix: AA01
Pubchem: 54454
Drugbank: APRD00104
C: 25 H=38 O=5
Molecular Weight: 418.566 g/mol
Smiles: CCC(C)(C)C(=O)OC@H1CC@@H(C)C=C2C=CC@H(C)C@H(CCC@@H3CC@@H(O)CC(= O)O3)C@@H12
Bioavailability: 5%
Protein Bound: 95%
Metabolism: Hepatic (CYP3A4)
Elimination Half-life: 3 hours
Excretion: Renal 13%, faecal (feces) 60%
Pregnancy Au: D
Pregnancy Us: X
Legal Au: S4
Legal Uk: P
Legal Us: Rx-only
Routes Of Administration: Oral