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Oxycodone is an opioid analgesic medication synthesized from opium-derived thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids in an attempt to improve on the existing opiates and opioids: morphine, diacetylmorphine (heroin), and codeine.

Oxycodone oral medications are generally prescribed for the relief of moderate to severe pain. Currently it is formulated as single ingredient products or compounded products. Some common examples of compounding are oxycodone with acetaminophen or NSAIDs such as ibuprofen. The formulations are available as generics but are also made under various brand names.

OxyContin is Purdue Pharmas brand for time-release single-ingredient oxycodone oral medication. The manufacturing rights to generic oxycodone time-release are under dispute.

Watchedfields: changed

Verifiedrevid: 267473871

Iupac Name: (5''R'',9''R'',13''S'',14''S'')-4,5?-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one

Image2: Oxycodone_balls_3d.png

Number on List: 76-42-6

Casno Ref: cascite

Synonyms: dihydrohydroxycodeinone, 14-hydroxydihydrocodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine

Chemspiderid: 4447649

Atc Prefix: N02

Atc Suffix: AA05

Atc Supplemental: ATCN02AA55 (in combinations)

Pubchem: 5284603

Drugbank: DB00497

C: 18 H=21 N=1 O=4

Molecular Weight: 315.364 g/mol

Smiles: COc1ccc2CC@@H3N(C)CCC@@45C@@H(Oc1c24)C(=O)CCC@@35O

Bioavailability: Up to 87%

Protein Bound: 45%

Metabolism: Hepatic (CYP450: 2D6 substrate)

Elimination Half-life: 3 - 4.5 hr

Pregnancy Category: B/D (prolonged use or in high doses at term)

Legal Au: Schedule 8

Legal Ca: Schedule I

Legal Uk: Class A (CD)

Legal Us: Schedule II

Routes Of Administration: oral, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural

Dependency Liability: Moderate - High

Excretion: Urine (19% unchanged)

source: wikipedia.org

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