Omeprazole (INN (International Nonproprietary Name)) (pronEngo??m?pr?zo?l) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (peptic ulcer) (PUD), gastroesophageal reflux disease (GORD/GERD), laryngopharyngeal reflux (LPR), and Zollinger-Ellison syndrome. It was first marketed in the US in 1989 by AstraZeneca under the brand names Losec and Prilosec, and is now also available from generic (Generic drug) manufacturers under various brand names. AstraZeneca markets omeprazole as Losec, Antra, Gastroloc, Mopral, Omepral, and Prilosec. Omeprazole is marketed as Zegerid by Santarus, Prilosec OTC by Procter & Gamble and Zegerid OTC by Schering-Plough. In India it is available as OMEZ (FGP). In Argentina it is made by Bago Laboratories S.A. and available there and in Ecuador as Ulcozol. Omeprazole is one of the most widely prescribed drugs internationally and is available over the counter (Over-the-counter substance) in some countries. Prilosec contains the active ingredient omeprazole and Prilosec OTC contains the active ingredient omeprazole magnesium.