Friday Night with Jonathan Ross (known as The Jonathan Ross Show in markets where it does not air on a Friday night) is a comical chat show presented by Jonathan Ross. It is on the British (United Kingdom) terrestrial TV channel BBC One and is broadcast at 10.35pm on Friday nights. It was first shown on 2 November 2001 and is in its seventeenth series. The programme features Ross take on current topics of conversation, guest interviews (usually 3 per show) and live music from both a guest music group and the house band. The most frequent guests are Ricky Gervais and Jack Dee (8 episodes each), and Eddie Izzard (7 episodes). Johnny Vegas, Sir David Attenborough, Stephen Fry, Simon Pegg and Jeremy Clarkson have each appeared in 5 episodes.

Friday Night with Jonathan Ross most recent series began on 4 September 2009. The programme is now also being broadcast in high-definition (high-definition television) on BBC HD. Studio TC4 in the BBC Television Centre in London, where the show is made, has recently been upgraded to HD, making it the third television studio in Television Centre to be upgraded to HD (others being Studios TC1 and TC8).

The show was pulled by the BBC on 29 October 2008 when Jonathan Ross and Russell Brand were both suspended from their TV and Radio shows, in the events after the Russell Brand Show prank telephone calls row. The show returned on 23 January 2009, attracting 5.1 million viewers.

On Friday 12 June 2009, the show began airing in the United States on BBC America at 8 p.m. EST.