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Cirrhosis (pron-ens??ro?s?s) is a consequence of chronic liver disease characterized by replacement of liver tissue (tissue (biology)) by fibrosis, scar tissue and regenerative nodules (nodule (medicine)) (lumps that occur as a result of a process in which damaged tissue is regenerated), leading to loss of liver function. Cirrhosis is most commonly caused by alcoholism, hepatitis B and C (hepatitis C), and fatty liver disease (non-alcoholic fatty liver disease) but has many other possible causes. Some cases are idiopathic, i.e., of unknown cause.

Ascites (fluid retention in the abdominal cavity) is the most common complication of cirrhosis and is associated with a poor quality of life, increased risk of infection, and a poor long-term outcome. Other potentially life-threatening complications are hepatic encephalopathy (confusion and coma) and bleeding from esophageal varices. Cirrhosis is generally irreversible, and treatment usually focuses on preventing progression and complications. In advanced stages of cirrhosis the only option is a liver transplant.

The word "cirrhosis" derives from Greek ??????, meaning tawny (the orange-yellow colour of the diseased liver). While the clinical entity was known before, it was Ren� Laennec who gave it the name "cirrhosis" in his 1819 work in which he also describes the stethoscope.

Diseasesdb: 2729

Icd10: ICD10K703k70, ICD10K717k70, ICD10K74k70

Icd9: ICD9571

Emedicinesubj: med

Emedicinetopic: 3183

Emedicine Mult: eMedicine2radio175

Meshid: D008103

source: wikipedia.org

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